The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. In this article, we discuss the possible functional consequences of this cleavage site in the viral cycle, pathogenicity and its potential implication in the development of antivirals.

Mots clés

2019-nCoV Antivirals Furin Maturation protease SARS-CoV Spike protein

Domaines

Biologie structurale [q-bio.BM] Virologie Maladies émergentes

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https://inserm.hal.science/inserm-02517696

Soumis le : jeudi 28 mai 2020-11:11:51

Dernière modification le : vendredi 6 septembre 2024-17:36:04

Dates et versions

inserm-02517696 , version 1 (28-05-2020)

Licence

Paternité - Pas d'utilisation commerciale - Pas de modification

Identifiants

HAL Id : inserm-02517696 , version 1
DOI : 10.1016/j.antiviral.2020.104742
PUBMED : 32057769
WOS : 000523597500019

Citer

Bruno Coutard, Coralie Valle, Xavier de Lamballerie, Bruno Canard, Nabil G Seidah, et al.. The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade. Antiviral Research, 2020, 176, pp.104742. ⟨10.1016/j.antiviral.2020.104742⟩. ⟨inserm-02517696⟩

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