Ion transport systems in human labial acinar cells - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles AJP - Gastrointestinal and Liver Physiology Year : 1996

Ion transport systems in human labial acinar cells

I. Valdez
  • Function : Author
P. Fox
  • Function : Author
R. Evans
  • Function : Author
R. Turner
  • Function : Author


Human labial acini were assayed for the presence of ion transport systems associated with salivary fluid secretion using microfluorometric methods. Na(+)-K(+)-Cl- contransport and Na+/H+ exchange activities (determined by their bumetanide and amiloride sensitivities, respectively) were found at levels approximately 50% of those seen in similarly assayed rat parotid acini, but little, if any, C1-/HCO3-exchange activity was observed. Also, when human labial acini were stimulated with the muscarinic agonist carbachol, little evidence of the intracellular acidification associated with HCO3- secretion by other salivary glands was found. Na+/H+ exchange activity in human labial acini was downregulated (approximately 40%) by beta-adrenergic stimulation and upregulated (approximately threefold) by muscarinic stimulation. In contrast, beta-adrenergic stimulation produced only a marginally significant increase in Na(+)-K(+)-Cl- cotransport activity, and muscarinic stimulation was without effect. We include that basolateral Na(+)-K(+)-Cl- cotransport appears to be the dominant mechanism driving Cl- secretion and thereby fluid secretion in this tissue.
No file

Dates and versions

inserm-02448216 , version 1 (22-01-2020)



M. Paulais, I. Valdez, P. Fox, R. Evans, R. Turner. Ion transport systems in human labial acinar cells. AJP - Gastrointestinal and Liver Physiology, 1996, 270 (1), pp.G213-G219. ⟨10.1152/ajpgi.1996.270.1.G213⟩. ⟨inserm-02448216⟩


10 View
0 Download



Gmail Facebook X LinkedIn More