Bone Sarcomas: From Biology to Targeted Therapies - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Sarcoma Year : 2012

Bone Sarcomas: From Biology to Targeted Therapies

Franck Tirode


Primary malignant bone tumours, osteosarcomas, and Ewing sarcomas are rare diseases which occur mainly in adolescents and young adults. With the current therapies, some patients remain very difficult to treat, such as tumour with poor histological response to preoperative CT (or large initial tumour volume for Ewing sarcomas not operated), patients with multiple metastases at or those who relapsed. In order to develop new therapies against these rare tumours, we need to unveil the key driving factors and molecular abnormalities behind the malignant characteristics and to broaden our understanding of the phenomena sustaining the metastatic phenotype and treatment resistance in these tumours. In this paper, starting with the biology of these tumours, we will discuss potential therapeutic targets aimed at increasing local tumour control, limiting metastatic spread, and finally improving patient survival.
Fichier principal
Vignette du fichier
2012.Sarcoma.EwingTherapies.Gaspar.pdf (1.2 Mo) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

inserm-02438743 , version 1 (14-01-2020)


Attribution - NoDerivatives



Nathalie Gaspar, Angela Di Giannatale, Birgit Geoerger, Françoise Rédini, Nadège Corradini, et al.. Bone Sarcomas: From Biology to Targeted Therapies. Sarcoma, 2012, 2012, pp.1-18. ⟨10.1155/2012/301975⟩. ⟨inserm-02438743⟩
28 View
45 Download



Gmail Facebook X LinkedIn More