Epigenetic Regulation by lncRNAs: An Overview Focused on UCA1 in Colorectal Cancer - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Cancers Année : 2018

Epigenetic Regulation by lncRNAs: An Overview Focused on UCA1 in Colorectal Cancer

Résumé

Colorectal cancers have become the second leading cause of cancer-related deaths. In particular, acquired chemoresistance and metastatic lesions occurring in colorectal cancer are a major challenge for chemotherapy treatment. Accumulating evidence shows that long non-coding (lncRNAs) are involved in the initiation, progression, and metastasis of cancer. We here discuss the epigenetic mechanisms through which lncRNAs regulate gene expression in cancer cells. In the second part of this review, we focus on the role of lncRNA Urothelial Cancer Associated 1 (UCA1) to integrate research in different types of cancer in order to decipher its putative function and mechanism of regulation in colorectal cancer cells. UCA1 is highly expressed in cancer cells and mediates transcriptional regulation on an epigenetic level through the interaction with chromatin modifiers, by direct regulation via chromatin looping and/or by sponging the action of a diversity of miRNAs. Furthermore, we discuss the role of UCA1 in the regulation of cell cycle progression and its relation to chemoresistance in colorectal cancer cells.
Fichier principal
Vignette du fichier
cancers-10-00440.pdf (2.2 Mo) Télécharger le fichier
Loading...

Dates et versions

inserm-02341333 , version 1 (31-10-2019)

Identifiants

Citer

Bernadette Neve, Nicolas Jonckheere, Audrey Vincent, Isabelle van Seuningen. Epigenetic Regulation by lncRNAs: An Overview Focused on UCA1 in Colorectal Cancer. Cancers, 2018, 10 (11), pp.440. ⟨10.3390/cancers10110440⟩. ⟨inserm-02341333⟩

Collections

INSERM UNIV-LILLE
51 Consultations
221 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More