Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Nature Communications Year : 2018

Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver

Gladys Ferrere
Badr Kiaf
  • Function : Author
Amine Toubal
Lucie Beaudoin
  • Function : Author
Agnès Lehuen
  • Function : Correspondent author
  • PersonId : 968677
  • IdHAL : agnes-lehuen

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Abstract

Liver fibrosis is the common response to chronic liver injury, and leads to cirrhosis and its complications. Persistent inflammation is a driving force of liver fibrosis progression. Mucosal-associated invariant T (MAIT) cells are non-conventional T cells that display altered functions during chronic inflammatory diseases. Here, we show that circulating MAIT cells are reduced in patients with alcoholic or non-alcoholic fatty liver disease-related cirrhosis while they accumulate in liver fibrotic septa. Using two models of chronic liver injury, we demonstrate that MAIT cell-enriched mice show increased liver fibrosis and accumulation of hepatic fibrogenic cells, whereas MAIT cell-deficient mice are resistant. Co-culture experiments indicate that MAIT cells enhance the proinflammatory properties of monocyte-derived macrophages, and promote mitogenic and proinflammatory functions of fibrogenic cells, via distinct mechanisms. Our results highlight the profibrogenic functions of MAIT cells and suggest that targeting MAIT cells may constitute an attractive antifibrogenic strategy during chronic liver injury.

Domains

Immunology
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Origin : Publication funded by an institution
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Dates and versions

inserm-02339519 , version 1 (30-10-2019)

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Pushpa Hegde, Emmanuel Weiss, Valérie Paradis, Jinghong Wan, Morgane Mabire, et al.. Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver. Nature Communications, 2018, 9 (1), pp.2146. ⟨10.1038/s41467-018-04450-y⟩. ⟨inserm-02339519⟩
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