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Journal Articles Genetic Epidemiology Year : 2019

Genetic overlap between autoimmune diseases and non‐Hodgkin lymphoma subtypes

Lennox Din , Mohammad Sheikh , Nikitha Kosaraju , Karin Ekström Smedby (1) , Sasha Bernatsky (2) , Sonja I Berndt (3) , Christine Skibola (4) , Alexandra Nieters (5) , Sophia Wang , James Mckay (6) , Pierluigi Cocco (7) , Marc Maynadié (8) , Lenka Foretova (9) , Anthony Staines (10) , Thomas Mack , Silvia Sanjosé , Timothy Vyse (11) , Leonid Padyukov (12) , Alain A. Monnereau (13) , Alan Arslan , Amy Moore (14) , Angela Brooks‐wilson , Anne Novak , Bengt Glimelius (15) , Brenda Birmann , Brian Link (16) , Carolyn Stewart , Claire Vajdic , Corinne Haioun (17) , Corrado Magnani , David Conti , David G Cox (18) , Delphine Casabonne , Demetrius Albanes (19) , Eleanor Kane , Eve Roman (20) , Giacomo Muzi , Gilles Salles (21) , Graham G Giles (22) , Hans‐olov Adami , Hervé Ghesquieres (23) , Immaculata Vivo , Jacqueline Clavel (13) , James Cerhan (24) , John Spinelli , Jonathan N Hofmann (25) , Joseph Vijai (26) , Karen Curtin (27) , Karen Costenbader , Kenan Onel , Kenneth Offit (28) , Lauren Teras , Lindsay M. Morton (3) , Lucia Conde , Lucia Miligi (29) , Mads Melbye (30) , Maria Grazia Ennas (31) , Mark Liebow , Mark P. Purdue (3) , Martha Glenn (27) , Melissa Southey (32) , Morris Din , Nathaniel Rothman (3) , Nicola Camp , Nicole Wong Doo , Nikolaus Becker (33) , Nisha Pradhan , Paige Bracci , Paolo Boffetta (34) , Paolo Vineis (35) , Paul Brennan (6) , Peter Kraft (36) , Qing Lan , Richard K. Severson (37) , Roel Vermeulen (38) , Roger L Milne (39) , Rudolph Kaaks , Ruth Travis (40) , Stephanie Weinstein , Stephen Chanock (41) , Stephen Ansell (24) , Susan Slager (24) , Tongzhang Zheng , Yawei Zhang (42) , Yolanda Benavente (43) , Zachary Taub , Lohith Madireddy , Pierre‐antoine Gourraud , Jorge R Oksenberg (44) , Wendy Cozen (45) , Henrik Hjalgrim , Pouya Khankhanian (44)
1 Department of Medicine
2 MUHC - McGill University Health Center [Montreal]
3 NCI-NIH - National Cancer Institute [Bethesda]
4 Emory University [Atlanta, GA]
5 Center for Chronic Immunodeficiency (CCI), University Medical Center Freiburg, Freiburg, Germany
6 IACR - International Agency for Cancer Research
7 Department of Public Health
8 Registre des hémopathies malignes de Côte d'Or
9 MUNI - Masaryk University [Brno]
10 GRAPHOS - IFROSS Recherche
11 Faculty of Medicine
12 Karolinska Institutet [Stockholm]
13 Epidémiologie environnementale des cancers
14 Department of Chemistry and Biochemistry [Boulder]
15 Uppsala Universitet [Uppsala]
16 Carver College of Medicine, University of Iowa
17 Service d'hématologie clinique
18 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
19 Division of Cancer Epidemiology and Genetics
20 Health Sciences
21 Service de Radio-Oncologie [Lyon]
22 University of Melbourne
23 Centre Léon Bérard [Lyon]
24 Mayo Clinic [Rochester]
25 Occupational and Environmental Epidemiology Branch [Bethesda, Maryland]
26 Memorial Sloane Kettering Cancer Center [New York]
27 Huntsman Cancer Institute
28 Clinical Genetics Service
29 ISPO - Cancer Prevention and Research Institute
30 Dept. of Epidemiology Research
31 B.B. Brodie Department of Neuroscience
32 Department of Pathology
33 Division of Cancer Epidemiology
34 Unit of Environment Cancer Epidemiology
35 University of Torino and CPO-Piemonte
36 Department of Epidemiology
37 Wayne State University [Detroit]
38 Division of Environmental Epidemiology
39 Cancer Epidemiology Centre
40 Cancer Epidemiology Unit
41 Division of Cancer Epidemiology and Genetics
42 MONARIS - De la Molécule aux Nanos-objets : Réactivité, Interactions et Spectroscopies
43 Department of Epidemiology
44 Department of Neurology [San Francisco, CA, USA]
45 Norris Comprehensive Cancer Center
Lennox Din
  • Function : Author
Mohammad Sheikh
  • Function : Author
Nikitha Kosaraju
  • Function : Author
Karin Ekström Smedby
  • Function : Author
  • PersonId : 887297
Sophia Wang
  • Function : Author
Anthony Staines
  • Function : Author
  • PersonId : 1042813
Thomas Mack
  • Function : Author
Silvia Sanjosé
  • Function : Author
Timothy Vyse
  • Function : Author
  • PersonId : 881649
Alan Arslan
  • Function : Author
Angela Brooks‐wilson
  • Function : Author
Anne Novak
  • Function : Author
Brenda Birmann
  • Function : Author
Carolyn Stewart
  • Function : Author
Claire Vajdic
  • Function : Author
Corrado Magnani
  • Function : Author
David Conti
  • Function : Author
Delphine Casabonne
Eleanor Kane
  • Function : Author
Eve Roman
  • Function : Author
  • PersonId : 906239
Giacomo Muzi
  • Function : Author
Gilles Salles
  • Function : Author
  • PersonId : 997016
Hans‐olov Adami
  • Function : Author
Immaculata Vivo
  • Function : Author
John Spinelli
  • Function : Author
Karen Costenbader
  • Function : Author
Kenan Onel
  • Function : Author
Lauren Teras
  • Function : Author
Lucia Conde
  • Function : Author
Mark Liebow
  • Function : Author
Melissa Southey
  • Function : Author
  • PersonId : 918639
Morris Din
  • Function : Author
Nathaniel Rothman
  • Function : Author
  • PersonId : 906255
Nicola Camp
  • Function : Author
Nicole Wong Doo
  • Function : Author
Nikolaus Becker
  • Function : Author
  • PersonId : 910633
Nisha Pradhan
  • Function : Author
Paige Bracci
  • Function : Author
Peter Kraft
Qing Lan
  • Function : Author
Rudolph Kaaks
  • Function : Author
Ruth Travis
  • Function : Author
  • PersonId : 950018
Stephanie Weinstein
  • Function : Author
Stephen Ansell
Susan Slager
  • Function : Author
  • PersonId : 1010875
Tongzhang Zheng
  • Function : Author
Yolanda Benavente
  • Function : Author
  • PersonId : 904182
Zachary Taub
  • Function : Author
Lohith Madireddy
  • Function : Author
Pierre‐antoine Gourraud
  • Function : Author
Henrik Hjalgrim
  • Function : Author

Abstract

Epidemiologic studies show an increased risk of non-Hodgkin lymphoma (NHL) in patients with autoimmune disease (AD), due to a combination of shared environmental factors and/or genetic factors, or a causative cascade: chronic inflammation/antigen-stimulation in one disease leads to another. Here we assess shared genetic risk in genome-wide-association-studies (GWAS). Secondary analysis of GWAS of NHL subtypes (chronic lymphocytic leukemia, diffuse large B-cell lymphoma, follicular lymphoma, and marginal zone lymphoma) and ADs (rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis). Shared genetic risk was assessed by (a) description of regional genetic of overlap, (b) polygenic risk score (PRS), (c)"diseasome", (d)meta-analysis. Descriptive analysis revealed few shared genetic factors between each AD and each NHL subtype. The PRS of ADs were not increased in NHL patients (nor vice versa). In the diseasome, NHLs shared more genetic etiology with ADs than solid cancers (p = .0041). A meta-analysis (combing AD with NHL) implicated genes of apoptosis and telomere length. This GWAS-based analysis four NHL subtypes and three ADs revealed few weakly-associated shared loci, explaining little total risk. This suggests common genetic variation, as assessed by GWAS in these sample sizes, may not be the primary explanation for the link between these ADs and NHLs.

Dates and versions

inserm-02286174 , version 1 (13-09-2019)

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Lennox Din, Mohammad Sheikh, Nikitha Kosaraju, Karin Ekström Smedby, Sasha Bernatsky, et al.. Genetic overlap between autoimmune diseases and non‐Hodgkin lymphoma subtypes. Genetic Epidemiology, 2019, ⟨10.1002/gepi.22242⟩. ⟨inserm-02286174⟩
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