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Poster De Conférence Année : 2019

Granzyme B-secreting B cells as a potential cell therapeutic

Résumé

B cells secreting granzyme B (GZMB+) with suppressive properties have been discovered in a growing number of immunological contexts, autoimmunity, chronic infection, and neoplasias, as well as in healthy volunteers under physiological conditions. To date, no phenotype has been proposed for these GZMB+ B cells, and their biology also remains uncharacterized. These data provide new insights into GZMB+ B cell biology and function that emerge as one component of a complex regulatory network. Successfully expanding these cells while maintaining their potent immunosuppressive properties provides new clues for novel future cell therapies.
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Dates et versions

inserm-02161909 , version 1 (21-06-2019)

Identifiants

  • HAL Id : inserm-02161909 , version 1

Citer

Mélanie Chesneau, Richard Danger, Sabine Le Bot, Cyrielle Poulaouec, Matthieu Filloux, et al.. Granzyme B-secreting B cells as a potential cell therapeutic. FOCIS 2019, Jun 2019, Boston, United States. ⟨inserm-02161909⟩
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