A composite score associated with spontaneous operational tolerance in kidney transplant recipients - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Kidney International Year : 2017

A composite score associated with spontaneous operational tolerance in kidney transplant recipients

Abstract

New challenges in renal transplantation include using biological information to devise a useful clinical test for discerning high- and low-risk patients for individual therapy and ascertaining the best combination and appropriate dosages of drugs. Based on a 20-gene signature from a microarray meta-analysis performed on 46 operationally tolerant patients and 266 renal transplant recipients with stable function, we applied the sparse Bolasso methodology to identify a minimal and robust combination of six genes and two demographic parameters associated with operational tolerance. This composite score of operational tolerance discriminated operationally tolerant patients with an area under the curve of 0.97 (95% confidence interval 0.94-1.00). The score was not influenced by immunosuppressive treatment, center of origin, donor type, or post-transplant lymphoproliferative disorder history of the patients. This composite score of operational tolerance was significantly associated with both de novo anti-HLA antibodies and tolerance loss. It was validated by quantitative polymerase chain reaction using independent samples and demonstrated specificity toward a model of tolerance induction. Thus, our score would allow clinicians to improve follow-up of patients, paving the way for individual therapy.
Fichier principal
Vignette du fichier
nihms856277.pdf (544.75 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

inserm-02156039 , version 1 (14-06-2019)

Identifiers

Cite

Richard Danger, Mélanie Chesneau, Chloé Paul, Pierrick Guérif, Maxim Durand, et al.. A composite score associated with spontaneous operational tolerance in kidney transplant recipients. Kidney International, 2017, 91 (6), pp.1473-1481. ⟨10.1016/j.kint.2016.12.020⟩. ⟨inserm-02156039⟩
59 View
122 Download

Altmetric

Share

Gmail Facebook X LinkedIn More