Choosing a practical and valid Image-Based Meta-Analysis
Résumé
Meta-analysis provides a quantitative approach to summarise the rich functional Magnetic Resonance Imaging (fMRI) literature. When image data is available for each study, the optimal approach is to perform an Image-Based Meta-Analysis (IBMA) [1]. A number of IBMA approaches have been proposed including combination of standardised statistics (Z's), just effect estimates (E's) or both effect estimates and their standard errors (SE's). While using both E’s & SE’s and estimating between-study variance should be optimal, the methods are not guaranteed to work for small number of studies. Also, often only standardised estimates are shared, reducing the possible meta-analytic approaches. Finally, because the BOLD signal is non-quantitative care has to be taken in order to insure that E's are expressed in the same units [2,3], especially when combining data from different software packages. Given the growing interest in data sharing in the neuroimaging community there is a need to identify what is the minimal data to be shared in order to allow for future IBMAs. Here, we investigate the validity of 8 IBMA approaches.
Domaines
Neurosciences [q-bio.NC]Origine | Fichiers produits par l'(les) auteur(s) |
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