Detecting and Interpreting Heterogeneity and Publication Bias in Image-Based Meta-Analyses
Résumé
With the increase of data sharing, meta-analyses are becoming increasingly important in the neuroimaging community. They provide a quantitative summary of published results and heightened confidence due to higher statistical power. The gold standard approach to combine results from neuroimaging studies is an Image-Based Meta-Analysis (IBMA) [1] in which group-level maps from different studies are combined.
Recently, we have introduced the IBMA toolbox, an extension for SPM that provides methods for combining image maps from multiple studies [2]. However, the current toolbox lacks diagnostic tools used to assess critical assumptions of meta-analysis, in particular whether there is inter-study variation requiring random-effects IBMA, and whether publication bias is present. Here, we present two new tools added to the IBMA toolbox to detect heterogeneity and to assess evidence of publication bias.
Domaines
Neurosciences [q-bio.NC]Origine | Fichiers produits par l'(les) auteur(s) |
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