The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Frontiers in Neuroscience Year : 2018

The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease

Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disorder in elderly people. AD is characterized by a progressive cognitive decline and it is neuropathologically defined by two hallmarks: extracellular deposits of aggregated β-amyloid (Aβ) peptides and intraneuronal fibrillar aggregates of hyper- and abnormally phosphorylated Tau proteins. AD results from multiple genetic and environmental risk factors. Epidemiological studies reported beneficial effects of caffeine, a non-selective adenosine receptors antagonist. In the present review, we discuss the impact of caffeine and of adenosinergic system modulation on AD, in terms of pathology and therapeutics.
Fichier principal
Vignette du fichier
fnins-12-00520.pdf (784.83 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Loading...

Dates and versions

inserm-01930487 , version 1 (22-11-2018)

Identifiers

Cite

Luc Cellai, Kevin Carvalho, Emilie Faivre, Aude Deleau, Didier Vieau, et al.. The Adenosinergic Signaling: A Complex but Promising Therapeutic Target for Alzheimer’s Disease. Frontiers in Neuroscience, 2018, 12, pp.520. ⟨10.3389/fnins.2018.00520⟩. ⟨inserm-01930487⟩
30 View
187 Download

Altmetric

Share

Gmail Facebook X LinkedIn More