Hepatitis C virus incidence in HIV-infected and in preexposure prophylaxis (PrEP)-using men having sex with men - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Liver International Year : 2018

Hepatitis C virus incidence in HIV-infected and in preexposure prophylaxis (PrEP)-using men having sex with men

1 Service des Maladies Infectieuses et Tropicales, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, 69004 Lyon, France
2 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
3 CHU Nice - Centre Hospitalier Universitaire de Nice
4 Département Maladies Infectieuses et Tropicales, Hôpital Universitaire, Montpellier, France
5 TransVIHMI - Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes
6 Service des maladies infectieuses et tropicales [CHU Nantes]
7 CIC Nantes - Centre d’Investigation Clinique de Nantes
8 Le Trait d'Union, centre de soins de l'infection par le VIH [CHU Strasbourg]
9 Service Maladies infectieuses et tropicales [CHU Toulouse]
10 CPTP - Centre de Physiopathologie Toulouse Purpan
11 UT3 - Université Toulouse III - Paul Sabatier
12 Service des maladies infectieuses [Saint-Etienne]
13 Service des Maladies Infectieuses et Tropicales [CHU Clermont-Ferrand]
14 CHU Pitié-Salpêtrière [AP-HP]
15 Département d'Hématologie [APHM - Assistance Publique - Hôpitaux de Marseille]
16 AMU - Aix Marseille Université
17 SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD - Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale
18 Service de Maladies Infectieuses et Tropicales [Fort-de-France, Martinique]
19 CIC - Antilles Guyane - Centre d'investigation clinique Antilles-Guyane
20 MAITC EA 4537 - Maladies infectieuses et tropicales dans la Caraïbe
21 Service des Maladies Infectieuses et Tropicales [Point-à-Pitre]
22 UCBL - Université Claude Bernard Lyon 1
23 Délégation à la Recherche Clinique et à l’Innovation [CHLS Lyon]
Romain Palich

Abstract

BACKGROUND & AIMS: HCV incidence still appears on the rise in HIV-infected MSM in France. We assessed the incidence of HCV infection in HIV-positive and in preexposure prophylaxis (PrEP)-using MSM. METHODS: HIV-infected, HCV-negative MSM with serological follow-up in 2016 and HIV-negative, HCV-negative PrEP-using MSM enrolled from January 2016 to May 2017 in the French Dat'AIDS cohort were analyzed to assess the incidence of a primary HCV infection. The incidence of HCV reinfection was also determined in patients having cured a previous infection. RESULTS: Among 10,049 HIV-infected MSM followed in 2016, 681 patients were already HCV-infected when entering the study (prevalence 6.8%). Serological follow-up was available in 2016 for 4,151 HCV-negative patients. Virological follow-up was available for 478 patients who had cured a previous infection. Fifty-seven HCV infections occurred in 2016 (42 primary infections, 15 reinfections). Incidence of primary HCV infection, reinfection and overall HCV infection was respectively 1.0, 3.1 and 1.2/100 person-years (PY). From January 2016 to May 2017, 930 HIV-negative subjects were enrolled for PrEP. Seventeen patients were already HCV-infected (prevalence 1.8%). Twelve HCV infections occurred during follow-up (10 primary infections, 2 reinfections) giving an incidence of primary infection of 1.0/100 PY and an overall incidence of 1.2/100 PY. CONCLUSIONS: The overall incidence of HCV infection and of a primary HCV infection in HIV-positive and in PrEP-using MSM appeared similar in France in 2016-early 2017. HIV-positive and PrEP-using MSM probably share similar at-risk practices and both should be targeted for preventative interventions.
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Dates and versions

inserm-01869902 , version 1 (06-09-2018)

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Laurent Cotte, Eric Cua, Jacques Reynes, François Raffi, David Rey, et al.. Hepatitis C virus incidence in HIV-infected and in preexposure prophylaxis (PrEP)-using men having sex with men. Liver International, 2018, Epub ahead of print. ⟨10.1111/liv.13922⟩. ⟨inserm-01869902⟩
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