HIF-1α and growth plate development: what we really know - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles BoneKEy Reports Year : 2015

HIF-1α and growth plate development: what we really know

Abstract

Adaptation to low oxygen tension or hypoxia is a critical event in development and tissue homeostasis. Studies by us and others have shown that the fetal growth plate is an avascular tissue with a gradient of oxygenation, and the transcription factor hypoxia-inducible factor-1α (HIF-1α) is essential for its development. In this brief review, we will summarize our current understanding of the role of HIF-1α in fetal growth plate development, and we will discuss yet unanswered questions in the field of hypoxia and endochondral bone formation.
Embargoed file
Embargoed file
Ne sera jamais visible
Loading...

Dates and versions

inserm-01846880 , version 1 (23-07-2018)

Identifiers

Cite

Ernestina Schipani, Laura Mangiavini, Christophe Merceron. HIF-1α and growth plate development: what we really know. BoneKEy Reports, 2015, 4, pp.730. ⟨10.1038/bonekey.2015.99⟩. ⟨inserm-01846880⟩
61 View
1 Download

Altmetric

Share

Gmail Facebook X LinkedIn More