Pro-Inflammatory Versus Anti-Inflammatory effects of dendrimers: The Two Faces of Immuno-Modulatory Nanoparticles
Résumé
Dendrimers are soft matter, hyperbranched, and multivalent nanoparticles whose synthesis
theoretically affords monodisperse compounds. They are built from a core on which one or
several successive series of branches are engrafted in an arborescent way. At the end of the
synthesis, the tunable addition of surface groups gives birth to multivalent nano-objects which
are generally intended for a specific use. For these reasons, dendrimers have received a lot of
attention from biomedical researchers. In particular, some of us have demonstrated that dendrimers
can be intrinsically drug-candidate for the treatment of inflammatory disorders, amongst others,
using relevant preclinical animal models. These anti-inflammatory dendrimers are innovative
in the pharmaceutical field. More recently, it has appeared that some dendrimers (even among
those which have been described as anti-inflammatory) can promote inflammatory responses in
non-diseased animals. The main corpus of this concise review is focused on the reports which
describe anti-inflammatory properties of dendrimers in vivo, following which we review the few
recent articles that show pro-inflammatory effects of our favorite molecules, to finally discuss this
duality in immuno-modulation which has to be taken into account for the preclinical and clinical
developments of dendrimers.
Fichier principal
fruchon 2017 nanomaterials Pro-Inflammatory Versus Anti-Inflammatory effects of dendrimers.pdf (377.14 Ko)
Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Loading...