Comparative Analysis of Protein -Protein Interface Methods
Résumé
In the cells, proteins are never alone. All proteins interact with other molecules to become functional. Protein-Protein interactions (PPIs) are essential for a broad range of cellular processes including signal transduction, cell-to-cell communication, transcription, replication, and membrane transport. So, studying PPIs is crucial to better understand the relationship between different protein partners and their functions. These interactions result in physical contacts of high specificity as a result of biochemical events steered by electrostatic forces including hydrophobic effect. Residues close in space determine protein contacts and computational approaches finding these residues are interesting for PPI studies.
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