Pleural Effusions from Patients with Mesothelioma Induce Recruitment of Monocytes and Their Differentiation into M2 Macrophages - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Journal of Thoracic Oncology Year : 2016

Pleural Effusions from Patients with Mesothelioma Induce Recruitment of Monocytes and Their Differentiation into M2 Macrophages

Abstract

Introduction: Mesothelioma is a rare and aggressive cancer related to asbestos exposure. We recently showed that pleural effusions (PEs) from patients with mesothelioma contain high levels of the CC motif chemokine ligand 2 (CCL2) inflammatory chemokine. In the present work, we studied the effect of CCL2 contained in mesothelioma samples , particularly on monocyte recruitment. Then, we studied the fate of these monocytes in malignant pleural mesotheli-oma (MPM) PEs and their impact on tumor cells' properties.

Domains

Cancer
Embargoed file
Embargoed file
Visibility date is undetermined
Loading...

Dates and versions

inserm-01386814 , version 1 (24-10-2016)

Identifiers

Cite

Anne-Laure Chéné, Sènan D’almeida, Thibaut Blondy, Julie Tabiasco, Sophie Deshayes, et al.. Pleural Effusions from Patients with Mesothelioma Induce Recruitment of Monocytes and Their Differentiation into M2 Macrophages. Journal of Thoracic Oncology, 2016, 11 (10), pp.1765 - 1773. ⟨10.1016/j.jtho.2016.06.022⟩. ⟨inserm-01386814⟩
155 View
1 Download

Altmetric

Share

Gmail Facebook X LinkedIn More