Awake hippocampal reactivations project onto orthogonal neuronal assemblies
Résumé
The chained activation of neuronal assemblies is thought to support major cognitive processes,
including memory. In the hippocampus, this is observed during population bursts often
associated with sharp-wave ripples, in the form of an ordered reactivation of neurons. However,
the organization and lifetime of these assemblies remain unknown.We used calcium imaging
to map patterns of synchronous neuronal activation in the CA1 region of awakemice during runs
on a treadmill.The patterns were composed of the recurring activation of anatomically
intermingled, but functionally orthogonal, assemblies.These assemblies reactivated discrete
temporal segments of neuronal sequences observed during runs and could be stable across
consecutive days. A binding of these assemblies into longer chains revealed temporally
ordered replay.
Domaines
Sciences du Vivant [q-bio]
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