A Ring-D-Seco-Tetranortriterpenoid from Seeds of Carapa procera Active against Breast Cancer Cell Lines.
Résumé
The seeds of Carapa procera are exploited extensively
in West African ethnopharmacy for the
treatment of several pathologies, including inflammation.
They also are effective as insect antifeedants
and as a mosquito repellent. With the
aim of identifying bioactive principles, an ethyl
acetate extract of the defatted seeds was made
and fractionated. Two principle compounds were
isolated. One of these, 5,6-dehydro-7-deacetoxy-
7-oxogedunin (1), while known from another genus
of the Meliaceae, is newly identified from the
genus Carapa and its X‑ray structure is described
for the first time. In addition, 1 displayed strong
anti-clonogenic activity at 10 μM. The other compound,
mexicanolide (2), is known from this
species and showed neither cytotoxicity nor anticlonogenicity.
These differences in efficacy are
discussed in relation to known structure-activity
relationships of limonoids.
Domaines
Cancer
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