Combined impact of smoking and heavy alcohol use on cognitive decline in early old age: Whitehall II prospective cohort study. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles The British journal of psychiatry : the journal of mental science Year : 2013

Combined impact of smoking and heavy alcohol use on cognitive decline in early old age: Whitehall II prospective cohort study.

Abstract

Identifying modifiable risk factors for cognitive decline may inform prevention of dementia. To examine the combined impact of cigarette smoking and heavy alcohol consumption on cognitive decline from midlife. Prospective cohort study (Whitehall II cohort) with three clinical examinations in 1997/99, 2002/04 and 2007/09. Participants were 6473 adults (72% men), mean age 55.76 years (s.d. = 6.02) in 1997/99. Four cognitive tests, assessed three times over 10 years, combined into a global z-score (mean 0, s.d. = 1). Age-related decline in the global cognitive score was faster in individuals who were smoking heavy drinkers than in non-smoking moderate alcohol drinkers (reference group). The interaction term (P = 0.04) suggested that the combined effects of smoking and alcohol consumption were greater than their individual effects. Adjusting for age, gender, education and chronic diseases, 10-year decline in global cognition was -0.42 z-scores (95% CI -0.45 to -0.39) for the reference group. In individuals who were heavy alcohol drinkers who also smoked the decline was -0.57 z-scores (95% CI -0.67 to -0.48); 36% faster than the reference group. Individuals who were smokers who drank alcohol heavily had a 36% faster cognitive decline, equivalent to an age-effect of 2 extra years over 10-year follow-up, compared with individuals who were non-smoking moderate drinkers.
Fichier principal
Vignette du fichier
Hagger-Johnson et al. BJP.pdf (420.21 Ko) Télécharger le fichier
Origin : Publication funded by an institution
Loading...

Dates and versions

inserm-01153653 , version 1 (20-05-2015)

Identifiers

Cite

Gareth Hagger-Johnson, Séverine Sabia, Eric John Brunner, Martin Shipley, Martin Bobak, et al.. Combined impact of smoking and heavy alcohol use on cognitive decline in early old age: Whitehall II prospective cohort study.. The British journal of psychiatry : the journal of mental science, 2013, 203 (2), pp.120-5. ⟨10.1192/bjp.bp.112.122960⟩. ⟨inserm-01153653⟩
50 View
213 Download

Altmetric

Share

Gmail Facebook X LinkedIn More