Human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein induces DNA damages through Activation-Induced cytidine Deaminase (AID) - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Conference Papers Year : 2014

Human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein induces DNA damages through Activation-Induced cytidine Deaminase (AID)

Abstract

How T cells are transformed by HTLV-1 is still unclear, but it is well accepted that the viral oncoprotein Tax is associated with genomic instability of infected cells. Tax has recently been shown to directly induce, in T cells, the expression of AID (Ishikawa C et al., Carcinogenesis, 2011), a cytidine deaminase whose physiologic expression is usually restricted to B cells, in which it initiates class-switch recombination and somatic hypermutations to reshape the primary antibody repertoire after antigen encounter. It is also well established that AID-mediated mutations outside of immunoglobulin gene locus are involved in the oncogenic transformation of B lymphocytes...
Fichier principal
Vignette du fichier
1742-4690-11-S1-O45.pdf (64.14 Ko) Télécharger le fichier
1742-4690-11-S1-O45.xml (4.76 Ko) Télécharger le fichier
Origin Publisher files allowed on an open archive
Format Other

Dates and versions

inserm-00924959 , version 1 (07-01-2014)

Identifiers

Cite

Aurélien Riquet, Sébastien Chevalier, Julien Villaudy, Louis Gazzolo, Jean Pierre Vartanian, et al.. Human T-cell leukemia virus type 1 (HTLV-1) Tax oncoprotein induces DNA damages through Activation-Induced cytidine Deaminase (AID). 16th Interntional Conference on Human Retroviruses: HTLV and Related Viruses, Jun 2013, Montreal, Canada. pp.O45, ⟨10.1186/1742-4690-11-S1-O45⟩. ⟨inserm-00924959⟩
308 View
275 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More