Role of the calcium-binding protein parvalbumin in short-term synaptic plasticity. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Proceedings of the National Academy of Sciences of the United States of America Year : 2000

Role of the calcium-binding protein parvalbumin in short-term synaptic plasticity.

Abstract

GABAergic (GABA = gamma-aminobutyric acid) neurons from different brain regions contain high levels of parvalbumin, both in their soma and in their neurites. Parvalbumin is a slow Ca(2+) buffer that may affect the amplitude and time course of intracellular Ca(2+) transients in terminals after an action potential, and hence may regulate short-term synaptic plasticity. To test this possibility, we have applied paired-pulse stimulations (with 30- to 300-ms intervals) at GABAergic synapses between interneurons and Purkinje cells, both in wild-type (PV+/+) mice and in parvalbumin knockout (PV-/-) mice. We observed paired-pulse depression in PV+/+ mice, but paired-pulse facilitation in PV-/- mice. In paired recordings of connected interneuron-Purkinje cells, dialysis of the presynaptic interneuron with the slow Ca(2+) buffer EGTA (1 mM) rescues paired-pulse depression in PV-/- mice. These data show that parvalbumin potently modulates short-term synaptic plasticity.
Embargoed file
Embargoed file
Ne sera jamais visible
Loading...

Dates and versions

inserm-00919583 , version 1 (17-12-2013)

Identifiers

Cite

Olivier Caillard, Herman Moreno, Beat Schwaller, Isabel Llano, Marco R. Celio, et al.. Role of the calcium-binding protein parvalbumin in short-term synaptic plasticity.. Proceedings of the National Academy of Sciences of the United States of America, 2000, 97 (24), pp.13372-7. ⟨10.1073/pnas.230362997⟩. ⟨inserm-00919583⟩

Collections

INSERM
96 View
1 Download

Altmetric

Share

Gmail Facebook X LinkedIn More