Cellular Mechanisms of Tissue Fibrosis. 5. Novel insights into liver fibrosis. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles American Journal of Physiology - Cell Physiology Year : 2013

Cellular Mechanisms of Tissue Fibrosis. 5. Novel insights into liver fibrosis.

Abstract

Liver fibrosis is the common scarring reaction associated with chronic liver injury that results from prolonged parenchymal cell injury and/or inflammation. The fibrogenic response is characterized by progressive accumulation of extracellular matrix components enriched in fibrillar collagens and a failure of matrix turnover. This process is driven by a heterogeneous population of hepatic myofibroblasts, which mainly derive from hepatic stellate cells and portal fibroblasts. Regression of fibrosis can be achieved by the successful control of chronic liver injury, owing to termination of the fibrogenic reaction following clearance of hepatic myofibroblasts and restoration of fibrolytic pathways. Understanding of the complex network underlying liver fibrogenesis has allowed the identification of a large number of antifibrotic targets, but no antifibrotic drug has as yet been approved. This review will highlight recent advances regarding the mechanisms that regulate liver fibrogenesis and fibrosis regression, with special focus on novel signaling pathways and the role of inflammatory cells. Translation of these findings to therapies will require continued efforts to develop multitarget therapeutic approaches that will improve the grim prognosis of liver cirrhosis.
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Dates and versions

inserm-00907999 , version 1 (22-11-2013)

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Ariane Mallat, Sophie Lotersztajn. Cellular Mechanisms of Tissue Fibrosis. 5. Novel insights into liver fibrosis.: Mechanisms of liver fibrosis. American Journal of Physiology - Cell Physiology, 2013, 305 (8), pp.C789-99. ⟨10.1152/ajpcell.00230.2013⟩. ⟨inserm-00907999⟩

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