Apelin stimulates both cholecystokinin and glucagon-like peptide 1 secretions in vitro and in vivo in rodents. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Peptides Year : 2013

Apelin stimulates both cholecystokinin and glucagon-like peptide 1 secretions in vitro and in vivo in rodents.

Abstract

Apelin is an enteric peptide that exerts several digestive functions such as stimulation of cell proliferation and cholecystokinin (CCK) secretion. We investigated using murine enteroendocrine cell line (STC-1) and rats if apelin-13 stimulates both CCK and glucagon-like peptide 1 (GLP-1) secretions. We demonstrated that, in vitro and in vivo, apelin-13 increases the release of these two hormones in a dose-dependent manner. Present data suggest that apelin may modulate digestive functions, food intake behavior and glucose homoeostasis via apelin-induced release of enteric CCK but also through a new incretin-releasing activity on enteric GLP-1.

Dates and versions

inserm-00853168 , version 1 (22-08-2013)

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Jean-Sébastien Wattez, Rozenn Ravallec, Benoit Cudennec, Claude Knauf, Pascal Dhulster, et al.. Apelin stimulates both cholecystokinin and glucagon-like peptide 1 secretions in vitro and in vivo in rodents.. Peptides, 2013, epub ahead of print. ⟨10.1016/j.peptides.2013.08.005⟩. ⟨inserm-00853168⟩
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