Selection of genes for gene-environment interaction studies: a candidate pathway-based strategy using asthma as an example. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Environmental Health Year : 2013

Selection of genes for gene-environment interaction studies: a candidate pathway-based strategy using asthma as an example.

Abstract

BACKGROUND: The identification of gene by environment (GxE) interactions has emerged as a challenging but essential task to fully understand the complex mechanism underlying multifactorial diseases. Until now, GxE interactions have been investigated by candidate approaches examining a small number of genes, or agnostically at the genome wide level. PRESENTATION OF THE HYPOTHESIS: In this paper, we propose a gene selection strategy for investigation of gene-environment interactions. This strategy integrates the information on biological processes shared by genes, the canonical pathways to which they belong and the biological knowledge related to the environment in the gene selection process. It relies on both bioinformatics resources and biological expertise. TESTING THE HYPOTHESIS: We illustrate our strategy by considering asthma, tobacco smoke as the environmental exposure, and genes sharing the same biological function of "response to oxidative stress". Our filtering strategy leads to a list of 12 pathways involving 104 genes for further GxE investigation. IMPLICATIONS OF THE HYPOTHESIS: By integrating the environment into the gene selection process, we expect that our strategy will improve the ability to identify the joint effects and interactions of environmental and genetic factors in disease.
Fichier principal
Vignette du fichier
1476-069X-12-56.pdf (193.18 Ko) Télécharger le fichier
1476-069X-12-56-S1.DOCX (340.42 Ko) Télécharger le fichier
1476-069X-12-56-S2.DOCX (118.46 Ko) Télécharger le fichier
1476-069X-12-56.xml (46.84 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Format : Other
Format : Other
Format : Other
Loading...

Dates and versions

inserm-00843444 , version 1 (11-07-2013)

Identifiers

Cite

Marta Rava, Ismaïl Ahmed, Florence Demenais, Margaux Sanchez, Pascale Tubert-Bitter, et al.. Selection of genes for gene-environment interaction studies: a candidate pathway-based strategy using asthma as an example.. Environmental Health, 2013, 12 (1), pp.56. ⟨10.1186/1476-069X-12-56⟩. ⟨inserm-00843444⟩
153 View
209 Download

Altmetric

Share

Gmail Facebook X LinkedIn More