Alzheimer disease: Aβ-independent processes-rethinking preclinical AD. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Nature Reviews Neurology Year : 2013

Alzheimer disease: Aβ-independent processes-rethinking preclinical AD.

Abstract

The amyloid cascade hypothesis, which posits that amyloid-β accumulation is the key event in Alzheimer disease neurodegeneration, has dominated the field for 20 years. Recent findings, however, show that neuronal-injury biomarkers are independent of amyloid-β, calling for reconsideration of the pathological cascade and assessment of alternative therapeutic strategies.
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inserm-00806868 , version 1 (12-08-2013)

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Gaël Chételat. Alzheimer disease: Aβ-independent processes-rethinking preclinical AD.. Nature Reviews Neurology, 2013, 9 (3), pp.123-4. ⟨10.1038/nrneurol.2013.21⟩. ⟨inserm-00806868⟩
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