Functions of TGF-β-Exposed Plasmacytoid Dendritic Cells. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Critical Reviews in Immunology Year : 2012

Functions of TGF-β-Exposed Plasmacytoid Dendritic Cells.

Abstract

Plasmacytoid dendritic cells (pDCs) belong to the family of dendritic cells and possess specific features that distinguish them from conventional dendritic cells. For instance, pDC are the main interferon-alpha-secreting cells. Plasmacytoid dendritic cells exert both proinflammatory and regulatory functions. This is attested by the involvement of pDC through interferon-alpha secretion in several autoimmune diseases, and by the implication of pDC in tolerance. The same is true for TGF-β that plays a dual role in inflammation. In this review, we discuss recent data on pDC and TGF-β interactions. As with many cell types, pDCs are able to respond to TGF-β using the classic Smad signaling pathway. In addition, pDCs are capable to secrete TGF-β, in particular in response to TGF-β exposure. Exposure of pDCs to TGF-β prevents type I interferon secretion in response to TLR7/9 ligands. In contrast, the consequences of TGF-β on the antigen-presenting cell capacities of pDC are less clear, since TGF-β-exposed pDCs may lead to both regulatory T-cell and interleukin-17-secreting cell polarization. Here, we discuss the factors that may influence this polarization. We also discuss how pDCs exposed to TGF-β may participate in tolerance induction and maintenance, or, on the contrary, in autoimmune diseases.

Domains

Immunology
Embargoed file
Embargoed file
Embargoed file
Embargoed file
Visibility date is undetermined
Embargoed file
Visibility date is undetermined
Embargoed file
Visibility date is undetermined
Loading...

Dates and versions

inserm-00804423 , version 1 (25-03-2013)

Identifiers

  • HAL Id : inserm-00804423 , version 1
  • PUBMED : 23428227

Cite

Philippe Saas, Sylvain Perruche. Functions of TGF-β-Exposed Plasmacytoid Dendritic Cells.. Critical Reviews in Immunology, 2012, 32 (6), pp.529-53. ⟨inserm-00804423⟩
145 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More