Research needs in allergy: an EAACI position paper, in collaboration with EFA. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Clinical and Translational Allergy Year : 2012

Research needs in allergy: an EAACI position paper, in collaboration with EFA.

Nikolaos Papadopoulos (1) , Ioana Agache (2) , Sevim Bavbek (3) , Beatrice Bilo (4) , Fulvio Braido (5) , Victoria Cardona (6) , Adnan Custovic (7) , Jan Demonchy (8) , Pascal Demoly (9) , Philippe Eigenmann (10) , Jacques Gayraud (11) , Clive Grattan (12) , Enrico Heffler (13) , Peter Hellings (14) , Marek Jutel (15) , Edward Knol (16) , Jan Lötvall (17) , Antonella Muraro (18) , Lars Poulsen (19) , Graham Roberts (20) , Peter Schmid-Grendelmeier (21) , Chrysanthi Skevaki (1) , Massimo Triggiani (22) , Ronald Vanree (23) , Thomas Werfel (24) , Breda Flood (25) , Susanna Palkonen (25) , Roberta Savli (25) , Pia Allegri (26) , Isabella Annesi-Maesano (27) , Francesco Annunziato (28) , Dario Antolin-Amerigo (29) , Christian Apfelbacher (30) , Miguel Blanca (31) , Ewa Bogacka (32) , Patrizia Bonadonna (33) , Matteo Bonini (34) , Onur Boyman (21) , Knut Brockow (35) , Peter Burney (36) , Jeroen Buters (37) , Indre Butiene (38) , Moises Calderon (39) , Lars Olaf Cardell (40) , Jean-Christoph Caubet (41) , Sevcan Celenk (42) , Ewa Cichocka-Jarosz (43) , Cemal Cingi (44) , Mariana Couto (45) , Nicolette Dejong (46) , Stefano del Giacco (47) , Nikolaos Douladiris (1) , Filippo Fassio (48) , Jean-Luc Fauquert (49) , Javier Fernandez (50) , Montserrat Fernandez Rivas (51) , Marta Ferrer (52) , Carsten Flohr (53) , James Gardner (54) , Jon Genuneit (55) , Philippe Gevaert (56) , Anna Groblewska (57) , Eckard Hamelmann (58) , Hans Jürgen Hoffmann (59) , Karin Hoffmann-Sommergruber (60) , Lilit Hovhannisyan (61) , Valérie Hox (14) , Frode Jahnsen (62) , Ömer Kalayci (63) , Ayse Füsun Kalpaklioglu (64) , Jörg Kleine-Tebbe (64) , George Konstantinou (65) , Marcin Kurowski (66) , Susanne Lau (67) , Roger Lauener (68) , Antti Lauerma (69) , Kirsty Logan (70) , Antoine Magnan (71) , Joanna Makowska (72) , Heidi Makrinioti (36) , Paraskevi Mangina (1) , Felicia Manole (73) , Adriano Mari (74) , Angel Mazon (75) , Clare Mills (76) , Ervinç Mingomataj (77) , Bodo Niggemann (78) , Gunnar Nilsson (79) , Markus Ollert (80) , Liam O'Mahony (81) , Serena O'Neil (17) , Gianni Pala (82) , Alberto Papi (83) , Gianni Passalacqua (84) , Michael Perkin (71) , Oliver Pfaar (85) , Constantinos Pitsios (86) , Santiago Quirce (87) , Ulrike Raap (24) , Monika Raulf-Heimsoth (88) , Claudio Rhyner (83) , Paula Robson-Ansley (89) , Rodrigo Rodrigues Alves (90) , Zeljka Roje (91) , Carmen Rondon (92) , Odilija Rudzeviciene (93) , Franziska Ruëff (94) , Maia Rukhadze (95) , Gabriele Rumi (96) , Cansin Sackesen (97) , Alexandra Santos (98, 99) , Annalisa Santucci (100) , Christian Scharf (101) , Carsten Schmidt-Weber (102) , Benno Schnyder (103) , Jürgen Schwarze (104) , Gianenrico Senna (105) , Svetlana Sergejeva (106) , Sven Seys (107) , Andrea Siracusa (108) , Isabel Skypala (39) , Milena Sokolowska (109) , Francois Spertini (110) , Radoslaw Spiewak (111) , Aline Sprikkelman (112) , Gunter Sturm (113) , Ines Swoboda (60) , Ingrid Terreehorst (114) , Elina Toskala (115) , Claudia Traidl-Hoffmann (35) , Carina Venter (116) , Berber Vlieg-Boerstra (46, 83) , Paul Whitacker (117) , Margitta Worm (118) , Paraskevi Xepapadaki (1) , Cezmi Akdis (83)
1 Allergy Department
2 Transylvania University
3 Ankara University
4 University Hospital Ospedali Riuniti
5 Allergy & Respiratory Diseases Clinic - DIMI
6 Vall d'Hebron University Hospital [Barcelona]
7 Respiratory Research Group
8 Department of Allergology
9 Département Pneumologie et Addictologie
10 Pediatric Allergy Unit
11 Allergologie
12 Dermatology Centre
13 Dipartimento di Scienze Mediche
14 Department of Otorhinolaryngology, Head, and Neck Surgery
15 Department of Clinical Immunology
16 Department of Dermatology/Allergology (G02* 124)
17 Department of Internal Medicine
18 Department of Pediatrics
19 Laboratory of Medical Allergology
20 Faculty of Medicine
21 Allergy Unit - Department of Dermatology
22 Neurologica Clinic
23 Department of Experimental Immunology
24 Department of Dermatology and Allergy
25 EFA - European Federation of Allergy
26 Ophthamology epmn
27 ESIM - Epidémiologie des maladies infectieuses et modélisation
28 Department of Internal Medicine
29 Allergology
30 UR - Universität Regensburg
31 Research Laboratory
32 Department of Internal Diseases, Geriatrics and Allergology
33 Allergy Unit
34 Department of Internal Medicine
35 Department of Dermatology
36 Respiratory Epidemiology and Public Health
37 CK-CARE, ZAUM - Center of Allergy & Environment
38 Pediatric Allergy Unit
39 Section of Allergy and Clinical Immunology
40 Division of ENT diseases
41 Department of Child and Adolescent Medicine
42 Department of Biology
43 Chair and Department of Pediatrics
44 Department of Otorhinolaryngology, Head and Neck Surgery
45 Serviço de Imunoalergologia
46 ErasmusMC
47 Department of Medical Sciences "M. Aresu"
48 Allergologia ed Immunologia Clinica
49 Pédiatre A
50 UMH University
51 Hospital Clínico San Carlos
52 Universidad de Navarra
53 Guy's and St Thomas' Hospital [London]
54 Royal Free Hospital [London, UK]
55 Universität Ulm - Ulm University [Ulm, Allemagne]
56 Ghent University Hospital
57 ICZMP - Polish Mother’s Memorial Hospital Research Institute [Lodz]
58 Klinik für Kinder und Jugendmedizin
59 Aarhus University Hospital
60 Medizinische Universität Wien = Medical University of Vienna
61 Institute of Molecular Biology
62 Oslo University Hospital [Oslo]
63 Pediatric Allergy and Asthma Unit
64 Allergie- & Asthma-Zentrum Berlin Westend
65 Department of Allergy and Clinical Immunology
66 Department of Immunology
67 Charité - UniversitätsMedizin = Charité - University Hospital [Berlin]
68 Hochgebirgsklinik
69 Skin and Allergy Hospital
70 King‘s College London
71 ITX - ITX - unité de recherche de l'institut du thorax
72 Department of Allergy and Clinical Immunology
73 University of Oradea
74 Center for Molecular Allergology
75 Unit of Pediatric allergy and Pneumology
76 Manchester Interdisciplinary Biocentre
77 Department of Allergology and Clinical Immunology
78 German Red Cross Hospital Westend
79 Centre for Allergy Research at Karolinska Institutet
80 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
81 Swiss Institute of Allergy and Asthma Research (SIAF)
82 Allergy and Immunology Unit
83 UniFE - Università degli Studi di Ferrara = University of Ferrara
84 Internal Medicine Pad Maragliano
85 Center for Rhinology and Allergology = Zentrum für Rhinologie und Allergologie
86 Dietetics and Nutritional Science Dept
87 Hospital La Paz Institute for Health Research
88 IPA - Institute for Prevention and Occupational Medicine of the German Social Accident Insurance
89 School of Life Sciences
90 Hospital Divino Espirito Santo de Ponta Delgada
91 ENT Department
92 Hospital Civil
93 Nr. 101 - Odilija Rudzeviciene
94 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
95 Center of Allergy & Immunology
96 Complesso Integrato Columbus
97 Department of Pediatric Allergy
98 Department of Pediatric Allergy
99 Immunoallergology Department
100 Rimini Infermi Hospital
101 Greifswald University Hospital
102 MRI TUM - Klinikum rechts der Isar
103 Clinic for Rheumatology and Clinical Immunology/Allergology
104 Edin. - University of Edinburgh
105 Azienda Ospedaliero-Universitaria
106 Institute of Technology
107 Department of Microbiology and Immunology
108 Occupational Medicine
109 Critical Care Medicine Department
110 Division of Immunology and Allergy [Lausanne, Suisse]
111 Department of Experimental Dermatology and Cosmetology
112 AMC - Academic Medical Center - Academisch Medisch Centrum [Amsterdam]
113 Department of Dermatology
114 Department of ENT and Pediatrics
115 Department of Otorhinolaryngology
116 Allergy Research Centre
117 SpR
118 Department of Dermatology
Nikolaos Papadopoulos
  • Function : Correspondent author
  • PersonId : 933632

Connectez-vous pour contacter l'auteur
Ioana Agache
  • Function : Author
  • PersonId : 934973
Sevim Bavbek
  • Function : Author
  • PersonId : 934974
Beatrice Bilo
  • Function : Author
  • PersonId : 934975
Fulvio Braido
  • Function : Author
  • PersonId : 873328
Adnan Custovic
  • Function : Author
  • PersonId : 934976
Jan Demonchy
  • Function : Author
  • PersonId : 934977
Pascal Demoly
Philippe Eigenmann
  • Function : Author
  • PersonId : 934978
Jacques Gayraud
  • Function : Author
  • PersonId : 934979
Clive Grattan
  • Function : Author
  • PersonId : 934980
Enrico Heffler
  • Function : Author
  • PersonId : 934981
Marek Jutel
  • Function : Author
  • PersonId : 934983
Jan Lötvall
  • Function : Author
  • PersonId : 933617
Antonella Muraro
  • Function : Author
  • PersonId : 933620
Lars Poulsen
  • Function : Author
  • PersonId : 934985
Graham Roberts
  • Function : Author
  • PersonId : 903316
Chrysanthi Skevaki
  • Function : Author
  • PersonId : 934987
Massimo Triggiani
  • Function : Author
  • PersonId : 863303
Ronald Vanree
  • Function : Author
  • PersonId : 894404
Thomas Werfel
  • Function : Author
  • PersonId : 934988
Breda Flood
  • Function : Author
  • PersonId : 934989
Susanna Palkonen
  • Function : Author
  • PersonId : 934990
Roberta Savli
  • Function : Author
  • PersonId : 934991
Pia Allegri
  • Function : Author
  • PersonId : 934992
Francesco Annunziato
  • Function : Author
  • PersonId : 934993
Dario Antolin-Amerigo
  • Function : Author
  • PersonId : 934994
Christian Apfelbacher
  • Function : Author
  • PersonId : 934995
Miguel Blanca
  • Function : Author
  • PersonId : 934996
Patrizia Bonadonna
  • Function : Author
  • PersonId : 934998
Matteo Bonini
  • Function : Author
  • PersonId : 934999
Onur Boyman
  • Function : Author
  • PersonId : 935000
Knut Brockow
  • Function : Author
  • PersonId : 935001
Peter Burney
  • Function : Author
  • PersonId : 935002
Jeroen Buters
  • Function : Author
  • PersonId : 935003
Indre Butiene
  • Function : Author
  • PersonId : 935004
Moises Calderon
  • Function : Author
  • PersonId : 933589
Lars Olaf Cardell
  • Function : Author
  • PersonId : 935005
Sevcan Celenk
  • Function : Author
  • PersonId : 935007
Ewa Cichocka-Jarosz
  • Function : Author
  • PersonId : 934997
Mariana Couto
  • Function : Author
  • PersonId : 935009
Nicolette Dejong
  • Function : Author
  • PersonId : 935010
Nikolaos Douladiris
  • Function : Author
  • PersonId : 935012
Filippo Fassio
  • Function : Author
  • PersonId : 935013
Jean-Luc Fauquert
  • Function : Author
  • PersonId : 935014
Javier Fernandez
  • Function : Author
  • PersonId : 935015
Montserrat Fernandez Rivas
  • Function : Author
  • PersonId : 933612
Marta Ferrer
  • Function : Author
  • PersonId : 935016
Carsten Flohr
  • Function : Author
  • PersonId : 935017
James Gardner
  • Function : Author
  • PersonId : 935018
Philippe Gevaert
  • Function : Author
  • PersonId : 935019
Eckard Hamelmann
  • Function : Author
  • PersonId : 935021
Hans Jürgen Hoffmann
  • Function : Author
  • PersonId : 935022
Lilit Hovhannisyan
  • Function : Author
  • PersonId : 935024
Frode Jahnsen
  • Function : Author
  • PersonId : 935026
Ömer Kalayci
  • Function : Author
  • PersonId : 935027
Marcin Kurowski
  • Function : Author
  • PersonId : 935030
Roger Lauener
  • Function : Author
  • PersonId : 935032
Antti Lauerma
  • Function : Author
  • PersonId : 935033
Kirsty Logan
  • Function : Author
  • PersonId : 935034
Heidi Makrinioti
  • Function : Author
  • PersonId : 935036
Paraskevi Mangina
  • Function : Author
  • PersonId : 935037
Felicia Manole
  • Function : Author
  • PersonId : 935038
Adriano Mari
  • Function : Author
  • PersonId : 935039
Angel Mazon
  • Function : Author
  • PersonId : 935040
Clare Mills
  • Function : Author
  • PersonId : 935041
Bodo Niggemann
  • Function : Author
  • PersonId : 935043
Serena O'Neil
  • Function : Author
  • PersonId : 935046
Gianni Pala
  • Function : Author
  • PersonId : 935047
Gianni Passalacqua
  • Function : Author
  • PersonId : 933623
Constantinos Pitsios
  • Function : Author
  • PersonId : 935050
Ulrike Raap
  • Function : Author
  • PersonId : 935052
Paula Robson-Ansley
  • Function : Author
  • PersonId : 935055
Zeljka Roje
  • Function : Author
  • PersonId : 935057
Carmen Rondon
  • Function : Author
  • PersonId : 935058
Odilija Rudzeviciene
  • Function : Author
  • PersonId : 935059
Maia Rukhadze
  • Function : Author
  • PersonId : 935061
Gabriele Rumi
  • Function : Author
  • PersonId : 935062
Cansin Sackesen
  • Function : Author
  • PersonId : 935063
Annalisa Santucci
  • Function : Author
  • PersonId : 935065
Christian Scharf
  • Function : Author
  • PersonId : 935066
Carsten Schmidt-Weber
  • Function : Author
  • PersonId : 935067
Jürgen Schwarze
  • Function : Author
  • PersonId : 935069
Gianenrico Senna
  • Function : Author
  • PersonId : 933626
Svetlana Sergejeva
  • Function : Author
  • PersonId : 935070
Sven Seys
  • Function : Author
  • PersonId : 935071
Andrea Siracusa
  • Function : Author
  • PersonId : 935072
Isabel Skypala
  • Function : Author
  • PersonId : 935073
Milena Sokolowska
  • Function : Author
  • PersonId : 935074
Gunter Sturm
  • Function : Author
  • PersonId : 935078
Ingrid Terreehorst
  • Function : Author
  • PersonId : 935080
Elina Toskala
  • Function : Author
  • PersonId : 935081
Claudia Traidl-Hoffmann
  • Function : Author
  • PersonId : 935082
Carina Venter
  • Function : Author
  • PersonId : 935083
Paul Whitacker
  • Function : Author
  • PersonId : 935085
SpR
Margitta Worm
  • Function : Author
  • PersonId : 935086
Paraskevi Xepapadaki
  • Function : Author
  • PersonId : 935087

Abstract

ABSTRACT: In less than half a century, allergy, originally perceived as a rare disease, has become a major public health threat, today affecting the lives of more than 60 million people in Europe, and probably close to one billion worldwide, thereby heavily impacting the budgets of public health systems. More disturbingly, its prevalence and impact are on the rise, a development that has been associated with environmental and lifestyle changes accompanying the continuous process of urbanization and globalization. Therefore, there is an urgent need to prioritize and concert research efforts in the field of allergy, in order to achieve sustainable results on prevention, diagnosis and treatment of this most prevalent chronic disease of the 21st century.The European Academy of Allergy and Clinical Immunology (EAACI) is the leading professional organization in the field of allergy, promoting excellence in clinical care, education, training and basic and translational research, all with the ultimate goal of improving the health of allergic patients. The European Federation of Allergy and Airways Diseases Patients' Associations (EFA) is a non-profit network of allergy, asthma and Chronic Obstructive Pulmonary Disorder (COPD) patients' organizations. In support of their missions, the present EAACI Position Paper, in collaboration with EFA, highlights the most important research needs in the field of allergy to serve as key recommendations for future research funding at the national and European levels.Although allergies may involve almost every organ of the body and an array of diverse external factors act as triggers, there are several common themes that need to be prioritized in research efforts. As in many other chronic diseases, effective prevention, curative treatment and accurate, rapid diagnosis represent major unmet needs. Detailed phenotyping/endotyping stands out as widely required in order to arrange or re-categorize clinical syndromes into more coherent, uniform and treatment-responsive groups. Research efforts to unveil the basic pathophysiologic pathways and mechanisms, thus leading to the comprehension and resolution of the pathophysiologic complexity of allergies will allow for the design of novel patient-oriented diagnostic and treatment protocols. Several allergic diseases require well-controlled epidemiological description and surveillance, using disease registries, pharmacoeconomic evaluation, as well as large biobanks. Additionally, there is a need for extensive studies to bring promising new biotechnological innovations, such as biological agents, vaccines of modified allergen molecules and engineered components for allergy diagnosis, closer to clinical practice. Finally, particular attention should be paid to the difficult-to-manage, precarious and costly severe disease forms and/or exacerbations. Nonetheless, currently arising treatments, mainly in the fields of immunotherapy and biologicals, hold great promise for targeted and causal management of allergic conditions. Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein.

Domains

Immunology
Fichier principal
Vignette du fichier
2045-7022-2-21.pdf (967.25 Ko) Télécharger le fichier
2045-7022-2-21.xml (220.26 Ko) Télécharger le fichier
Origin : Publisher files allowed on an open archive
Format : Other
Loading...

Dates and versions

inserm-00771547 , version 1 (08-01-2013)

Identifiers

Cite

Nikolaos Papadopoulos, Ioana Agache, Sevim Bavbek, Beatrice Bilo, Fulvio Braido, et al.. Research needs in allergy: an EAACI position paper, in collaboration with EFA.. Clinical and Translational Allergy, 2012, 2 (1), pp.21. ⟨10.1186/2045-7022-2-21⟩. ⟨inserm-00771547⟩
1583 View
538 Download

Altmetric

Share

Gmail Facebook X LinkedIn More