Spatial learning depends on both the addition and removal of new hippocampal neurons. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles PLoS Biology Year : 2007

Spatial learning depends on both the addition and removal of new hippocampal neurons.

Abstract

The role of adult hippocampal neurogenesis in spatial learning remains a matter of debate. Here, we show that spatial learning modifies neurogenesis by inducing a cascade of events that resembles the selective stabilization process characterizing development. Learning promotes survival of relatively mature neurons, apoptosis of more immature cells, and finally, proliferation of neural precursors. These are three interrelated events mediating learning. Thus, blocking apoptosis impairs memory and inhibits learning-induced cell survival and cell proliferation. In conclusion, during learning, similar to the selective stabilization process, neuronal networks are sculpted by a tightly regulated selection and suppression of different populations of newly born neurons.
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Dates and versions

inserm-00708252 , version 1 (14-06-2012)

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David Dupret, Annabelle Fabre, Màtè Dàniel Döbrössy, Aude Panatier, José Julio Rodríguez, et al.. Spatial learning depends on both the addition and removal of new hippocampal neurons.. PLoS Biology, 2007, 5 (8), pp.e214. ⟨10.1371/journal.pbio.0050214⟩. ⟨inserm-00708252⟩

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