Molecular alterations associated with osteosarcoma development.
Abstract
Osteosarcoma is the most frequent malignant primary bone tumor characterized by a high potency to form lung metastases which is the main cause of death. Unfortunately, the conventional chemotherapy is not fully effective on osteosarcoma metastases. The progression of a primary tumor to metastasis requires multiple processes, which are neovascularization, proliferation, invasion, survival in the bloodstream, apoptosis resistance, arrest at a distant organ, and outgrowth in secondary sites. Consequently, recent studies have revealed new insights into the molecular mechanisms of metastasis development. The understanding of the mechanism of molecular alterations can provide the identification of novel therapeutic targets and/or prognostic markers for osteosarcoma treatment to improve the clinical outcome.
Fichier principal
Manuscript_revised_manuscript.pdf (503.16 Ko)
Télécharger le fichier
Figure_1.pdf (264.32 Ko)
Télécharger le fichier
Figure_2.pdf (196.73 Ko)
Télécharger le fichier
Origin : Publisher files allowed on an open archive
Origin : Publisher files allowed on an open archive
Origin : Publisher files allowed on an open archive
Loading...