[The role of co-inhibitory signals driven by CTLA-4 in immune system]. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Médecine/Sciences Year : 2011

[The role of co-inhibitory signals driven by CTLA-4 in immune system].

Abstract

Key players on the immunosurveillance program, T cells are regulated by their surface receptors such as T-cell receptor (TCR), and costimulatory molecules, optimizing T-cell activation. Some of these costimulatory molecules, such as the cytotoxic T-lymphocyte antigen 4 (CTLA-4), induce inhibitory effects on T cells. By "inhibiting the inhibitor" CTLA-4-blocking monoclonal antibodies represent a novel class of weapons against cancers. To better understand the promising future and the limits of this immunotherapy, this review dissects the molecular inhibitory mechanisms induced by CTLA-4 in T cells.

Domains

Immunology
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Dates and versions

inserm-00659319 , version 1 (21-10-2012)

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Cite

Daniel Olive, Suong Le Thi, Luc Xerri, Ivan Hirsch, Jacques A. Nunès. [The role of co-inhibitory signals driven by CTLA-4 in immune system].. Médecine/Sciences, 2011, 27 (10), pp.842-9. ⟨10.1051/medsci/20112710012⟩. ⟨inserm-00659319⟩

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