Vasopressin, ATP and catecholamines differentially control potassium secretion in inner ear cell line. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles FEBS Letters Year : 2011

Vasopressin, ATP and catecholamines differentially control potassium secretion in inner ear cell line.

Abstract

A strict control of endolymph composition (high potassium, low sodium fluid) and volume is instrumental for a proper functioning of the inner ear. Alteration of endolymph homeostasis is proposed in the pathogenesis of Menière's disease. However, the mechanisms controlling endolymph secretion remain elusive. By using the vestibular EC5v cells, we provide evidence for the presence of vasopressin, catecholamine and purinergic signaling pathways, coupled to adenylate cyclase, phosphoinositidase C and Ca(2+) activation. We demonstrate that vasopressin and catecholamines stimulate while ATP inhibits apical potassium secretion by EC5v cells. These results open new interesting perspectives for the management of inner ear diseases.
Fichier principal
Vignette du fichier
Figures_Nevoux.pdf (144.63 Ko) Télécharger le fichier
Nevoux_FEBS_HAL.pdf (187.03 Ko) Télécharger le fichier
Supplemental_Figures_Nevoux.pdf (1.38 Mo) Télécharger le fichier
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)
Format : Other

Dates and versions

inserm-00656238 , version 1 (13-09-2012)

Identifiers

Cite

Jérôme Nevoux, Marie Teixeira, Say Viengchareun, Claudine Cosson, Daniel Butlen, et al.. Vasopressin, ATP and catecholamines differentially control potassium secretion in inner ear cell line.. FEBS Letters, 2011, 585 (17), pp.2703-8. ⟨10.1016/j.febslet.2011.07.025⟩. ⟨inserm-00656238⟩
380 View
416 Download

Altmetric

Share

Gmail Facebook X LinkedIn More