%0 Journal Article %T Vasopressin, ATP and catecholamines differentially control potassium secretion in inner ear cell line. %+ Récepteurs stéroïdiens : physiopathologie endocrinienne et métabolique %+ Chirurgie otologique mini-invasive robotisée %+ Service de Biochimie [Bicêtre] %+ Service d'Endocrinologie et Maladies de la reproduction %+ Service d'ORL %A Nevoux, Jérôme %A Teixeira, Marie %A Viengchareun, Say %A Cosson, Claudine %A Butlen, Daniel %A Lombes, Marc %A Ferrary, Evelyne %Z This work was supported by grants from Inserm, Université Paris Diderot, Université Paris-Sud, European Section of Aldosterone Council (ESAC) and a fellowship from the Société Française d'Oto-Rhino-Laryngologie (to JN). %< avec comité de lecture %@ 0014-5793 %J FEBS Letters %I Wiley %V 585 %N 17 %P 2703-8 %8 2011-09-02 %D 2011 %R 10.1016/j.febslet.2011.07.025 %M 21820436 %K endolymph %K vasopressin receptors %K Menière's disease %K vestibular cells %K purinergic receptors %Z Life Sciences [q-bio]/Human health and pathology/Sensory OrgansJournal articles %X A strict control of endolymph composition (high potassium, low sodium fluid) and volume is instrumental for a proper functioning of the inner ear. Alteration of endolymph homeostasis is proposed in the pathogenesis of Menière's disease. However, the mechanisms controlling endolymph secretion remain elusive. By using the vestibular EC5v cells, we provide evidence for the presence of vasopressin, catecholamine and purinergic signaling pathways, coupled to adenylate cyclase, phosphoinositidase C and Ca(2+) activation. We demonstrate that vasopressin and catecholamines stimulate while ATP inhibits apical potassium secretion by EC5v cells. These results open new interesting perspectives for the management of inner ear diseases. %G English %2 https://inserm.hal.science/inserm-00656238/document %2 https://inserm.hal.science/inserm-00656238/file/Figures_Nevoux.pdf %2 https://inserm.hal.science/inserm-00656238/file/Nevoux_FEBS_HAL.pdf %L inserm-00656238 %U https://inserm.hal.science/inserm-00656238 %~ INSERM %~ UNIV-PARIS7 %~ UNIV-PSUD %~ APHP %~ UNIV-PARIS-SACLAY %~ UNIV-PSUD-SACLAY %~ UNIV-PARIS %~ PHYSENDO