Regulation of cell death by sphingosine 1-phosphate lyase. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Autophagy Year : 2010

Regulation of cell death by sphingosine 1-phosphate lyase.

Abstract

By controlling sphingosine 1-phosphate (S1P) catabolism, S1P lyase (SPL) represents an undeniable candidate as potential regulator of a cancer cell's fate in response to stress. Our recent study reveals that complete loss of SPL activity leads to upregulation of the anti-apoptotic proteins Bcl-2 and Bcl-xL and consequently protects against apoptosis induced by chemotherapy and nutrient starvation but not against autophagy. Here, we speculate on how S1P and disruption of S1P breakdown may regulate cell death and autophagy.
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Dates and versions

inserm-00613705 , version 1 (05-08-2011)

Identifiers

  • HAL Id : inserm-00613705 , version 1
  • PUBMED : 20215862

Cite

Sandra Colié, Patrice Codogno, Thierry Levade, Nathalie Andrieu-Abadie. Regulation of cell death by sphingosine 1-phosphate lyase.. Autophagy, 2010, 6 (3), pp.426-7. ⟨inserm-00613705⟩
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