IL4I1: an inhibitor of the CD8(+) antitumor T-cell response in vivo. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles European Journal of Immunology Year : 2011

IL4I1: an inhibitor of the CD8(+) antitumor T-cell response in vivo.

Abstract

The L-phenylalanine oxidase IL4I1 inhibits T-cell proliferation in vitro through H(2) O(2) production, and is highly expressed in tumor-associated macrophages. IL4I1 is also detected by immunohistochemistry in neoplastic cells from several B-cell lymphomas and some non-lymphoid tumors. To evaluate IL4I1's effect on tumor growth, we developed a mouse melanoma model constitutively coexpressing IL4I1 and the GP33 epitope. After GP33 vaccination, tumors developed more frequently in mice injected with IL4I1-expressing cells in comparison with mice receiving control cells. Tumor escape was preceded by a rapid diminution of IFN-γ-producing cytotoxic antitumor CD8(+) T cells. Moreover, tumor incidence was already increased when only 20% of the injected cells expressed IL4I1. The minimal IL4I1 activities leading to tumor escape were close to those detected in human melanoma and mesothelioma. Thus, we demonstrate the immunosuppressive functions of IL4I1 in vivo and suggest that IL4I1 facilitates human tumor growth by inhibiting the CD8(+) antitumor T-cell response.
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Origin : Files produced by the author(s)
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)

Dates and versions

inserm-00604898 , version 1 (30-06-2011)

Identifiers

Cite

Fanette Lasoudris, Céline Cousin, Armelle Prevost-Blondel, Nadine Martin-Garcia, Issam Abd-Alsamad, et al.. IL4I1: an inhibitor of the CD8(+) antitumor T-cell response in vivo.. European Journal of Immunology, 2011, 41 (6), pp.1629-38. ⟨10.1002/eji.201041119⟩. ⟨inserm-00604898⟩
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