Impact of recommendations on the initial therapy of Parkinson's disease: a population-based study in France. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Parkinsonism & Related Disorders Year : 2011

Impact of recommendations on the initial therapy of Parkinson's disease: a population-based study in France.

Emmanuel Roze
Frédéric Moisan
Jean Houssinot
  • Function : Author
Jean-Luc Dupupet
  • Function : Author
Elsa Krim
  • Function : Author
Christophe Tzourio

Abstract

Levodopa induces long-term motor complications in Parkinson's disease (PD). Therapeutic strategies that prevent motor complications are needed. Our aim was to evaluate the impact of recommendations of a French consensus conference published in 2000 on initial PD therapy. We identified 308 PD patients as part of a population-based study performed within the Mutualité Sociale Agricole in five French districts (2007). Neurologists confirmed PD diagnosis. We compared initial therapy in 102 patients treated before 12/31/2000 to that of 206 patients treated afterwards. Initial treatment was in agreement with the recommendations if dopamine agonists were used in patients <60 years (n = 49) and levodopa in patients ≥70 years (n = 133). Agreement with the recommendations increased after 2000 (66.0%) compared to before (46.3%, p = 0.025). For patients <60 years, agreement increased (64.0% vs 20.2%, p = 0.017) while it remained stable (66.4% vs 70.6%, p = 0.73) in patients ≥70 years. The publication of recommendations has influenced initial treatment choices for PD in France.
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inserm-00598387 , version 1 (06-06-2011)

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Claudine Fayard, Audrey Bonaventure, Isabelle Benatru, Emmanuel Roze, Julien Dumurgier, et al.. Impact of recommendations on the initial therapy of Parkinson's disease: a population-based study in France.. Parkinsonism & Related Disorders, 2011, 17 (7), pp.543-6. ⟨10.1016/j.parkreldis.2011.04.020⟩. ⟨inserm-00598387⟩
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