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Journal Articles Journal of Neurochemistry Year : 2011

A role for V-ATPase subunits in synaptic vesicle fusion?


J. Neurochem. (2011) 10.1111/j.1471-4159.2011.07234.x ABSTRACT: SNARE (soluble N-ethylmaleimide sensitive factor attachment protein receptors)-mediated exocytotic release of neurotransmitters is a key process in neuronal communication, controlled by a number of molecular interactions. A synaptic vesicle v-SNARE protein (VAMP2 or synaptobrevin), in association with two plasma membrane t-SNAREs (syntaxin 1 and SNAP25), assemble to form a protein complex that is largely accepted as the minimal membrane fusion machine. Acidification of the synaptic vesicle lumen by the large multi-subunit vacuolar proton pump (V-ATPase) is required for loading with neurotransmitters. Recent data demonstrate a direct interaction between the c-subunit of the V-ATPase and VAMP2 that appears to play a role at a late step in transmitter release. In this review, we examine evidence suggesting that the V0 membrane sector of the V-ATPase not only participates in proton pumping, but plays a second distinct role in neurosecretion, downstream of filling and close to vesicle fusion.
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inserm-00581211 , version 1 (30-03-2011)



Oussama El Far, Michael Seagar. A role for V-ATPase subunits in synaptic vesicle fusion?. Journal of Neurochemistry, 2011, 117, pp.603-612. ⟨10.1111/j.1471-4159.2011.07234.x⟩. ⟨inserm-00581211⟩
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