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Journal Articles Journal of Thoracic Oncology Year : 2011

International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.

1 Department of Pathology
2 Département d'anatomie et cythologie pathologique
3 Department of Pathology
4 Department of histopathology
5 Department of Pathology
6 Department of Pathology and Molecular Diagnostics
7 University of Michigan [Ann Arbor]
8 Columbia University [New York]
9 Thoracic Oncology Service
10 UA - University of Antwerp
11 Department of Radiology
12 Department of Radiology
13 Department of Thoracic Surgery
14 Department of Thoracic Surgery
15 University of Colorado Cancer Center
16 Department of Thoracic Oncology
17 Aichi Cancer Center Hospital
18 Pneumologie
19 Department of Pathology
20 Oncology and Pulmonary and Critical Care Medicine
21 IDIBELL - Institut d'Investigació Biomèdica de Bellvitge = Bellvitge Biomedical Research Institute
22 Department of Medicine
23 Div. of Molecular Carcinogenesis
24 Department of Thoracic Surgery
25 Department of Pulmonology
26 Departments of Pathology and Thoracic/Head and Neck Medical Oncology
27 Department of Internal Medicine
28 Department of Radiology
29 INSERM U823 - Institut d'oncologie/développement Albert Bonniot de Grenoble
30 Department of Pathology
31 Department of Pathology
32 Department of Pathology
33 Pulmonary Medicine
34 Dept of Histopathology
35 Flinders Medical Centre
36 Dana-Farber Cancer Institute [Boston]
37 Department of Internal Medicine
38 Department of Pathology
39 Department of Radiology
40 National Cancer Center Korea
41 Institute of pathology
42 Medical Center [Durham]
43 Medical Oncology Service
44 Medical Oncology Division
45 Department of Pathology
46 Department of Pathology
47 Department of Radiology
William D. Travis
  • Function : Correspondent author
  • PersonId : 891036

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Rudolf M. Huber
  • Function : Author
Masahiro Tsuboi
Michael Gould
  • Function : Author

Abstract

This new classification strategy is based on a multidisciplinary approach to diagnosis of lung adenocarcinoma that incorporates clinical, molecular, radiologic, and surgical issues, but it is primarily based on histology. This classification is intended to support clinical practice, and research investigation and clinical trials. As EGFR mutation is a validated predictive marker for response and progression-free survival with EGFR tyrosine kinase inhibitors in advanced lung adenocarcinoma, we recommend that patients with advanced adenocarcinomas be tested for EGFR mutation. This has implications for strategic management of tissue, particularly for small biopsies and cytology samples, to maximize high-quality tissue available for molecular studies. Potential impact for tumor, node, and metastasis staging include adjustment of the size T factor according to only the invasive component (1) pathologically in invasive tumors with lepidic areas or (2) radiologically by measuring the solid component of part-solid nodules.
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Dates and versions

inserm-00561753 , version 1 (01-02-2012)

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William D. Travis, Elisabeth Brambilla, Masayuki Noguchi, Andrew G. Nicholson, Kim R. Geisinger, et al.. International association for the study of lung cancer/american thoracic society/european respiratory society international multidisciplinary classification of lung adenocarcinoma.. Journal of Thoracic Oncology, 2011, 6 (2), pp.244-85. ⟨10.1097/JTO.0b013e318206a221⟩. ⟨inserm-00561753⟩

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