Caspase-10-dependent cell death in Fas/CD95 signalling is not abrogated by caspase inhibitor zVAD-fmk. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles PLoS ONE Year : 2010

Caspase-10-dependent cell death in Fas/CD95 signalling is not abrogated by caspase inhibitor zVAD-fmk.

Abstract

Altogether, these data provide genetic evidence for the involvement of initiator caspase-10 in FasL-induced cell death and indicate that zVAD-fmk does not abrogate caspase-10 processing and cytotoxicity in Fas signalling. Our study also questions the existence of an alternative caspase-independent cell death pathway in Fas signalling.
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Dates and versions

inserm-00550848 , version 1 (03-01-2011)

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Elodie Lafont, Delphine Milhas, Justin Teissié, Nicole Therville, Nathalie Andrieu-Abadie, et al.. Caspase-10-dependent cell death in Fas/CD95 signalling is not abrogated by caspase inhibitor zVAD-fmk.. PLoS ONE, 2010, 5 (10), pp.e13638. ⟨10.1371/journal.pone.0013638⟩. ⟨inserm-00550848⟩
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