Increased phosphorylation of vimentin in noninfiltrative meningiomas. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles PLoS ONE Year : 2010

Increased phosphorylation of vimentin in noninfiltrative meningiomas.


BACKGROUND: Tissue invasion or tissue infiltration are clinical behaviors of a poor-prognosis subset of meningiomas. We carried out proteomic analyses of tissue extracts to discover new markers to accurately distinguish between infiltrative and noninfiltrative meningiomas. METHODOLOGY/PRINCIPAL FINDINGS: Protein lysates of 64 different tissue samples (including two brain-invasive and 32 infiltrative tumors) were submitted to SELDI-TOF mass spectrometric analysis. Mass profiles were used to build up both unsupervised and supervised hierarchical clustering. One marker was found at high levels in noninvasive and noninfiltrative tumors and appeared to be a discriminative marker for clustering infiltrative and/or invasive meningiomas versus noninvasive meningiomas in two distinct subsets. Sensitivity and specificity were 86.7% and 100%, respectively. This marker was purified and identified as a multiphosphorylated form of vimentin, a cytoskeletal protein expressed in meningiomas. CONCLUSIONS/SIGNIFICANCE: Specific forms of vimentin can be surrogate molecular indicators of the invasive/infiltrative phenotype in tumors.
Fichier principal
Vignette du fichier
journal.pone.0009238.pdf (585.4 Ko) Télécharger le fichier
Origin Publisher files allowed on an open archive

Dates and versions

inserm-00514192 , version 1 (01-09-2010)



Ali Bouamrani, Claire Ramus, Emmanuel P. Gay, Laurent Pelletier, Myriam Cubizolles, et al.. Increased phosphorylation of vimentin in noninfiltrative meningiomas.. PLoS ONE, 2010, 5 (2), pp.e9238. ⟨10.1371/journal.pone.0009238⟩. ⟨inserm-00514192⟩
390 View
156 Download



Gmail Mastodon Facebook X LinkedIn More