Donor-derived oral squamous cell carcinoma after allogeneic bone marrow transplantation. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Blood Année : 2009

Donor-derived oral squamous cell carcinoma after allogeneic bone marrow transplantation.

Hugues de Thé

Résumé

In animal models, tissue stem cells were proposed to exhibit an unexpected level of plasticity, although issues on cell fusions have lead to some controversies. Only transplantation experiments using genetically distinct recipients and donors can unequivocally show these changes in cell fate. We have analyzed oral squamous cell carcinomas arising in 8 long-term survivors of allogeneic bone marrow transplantation, in whom chronic graft-versus-host disease greatly favors development of squamous cell carcinomas, possibly as a consequence of lichenoid mucosal inflammation. With the use of 2 independent methods, (1) combined immunostaining and fluorescent in situ hybridization (FISH) analysis for X and Y chromosomes sequences in sex-mismatched grafts and (2) comparison of microsatellite typing of laser-microdissected tumor, donor, and recipient cells, in all tumors, we showed that 4 of these 8 epithelial tumors actually arose from the engrafted allogeneic bone marrow. Thus, donor-derived bone marrow cells, whether hematopoietic or mesenchymal, recruited to sites of chronic mucosal inflammation yielded epithelial tumors. Our observations therefore show that marrow cells in humans have a major role in epithelial cancer formation after allogeneic transplantation.

Domaines

Cancer
Fichier sous embargo
Fichier sous embargo
Date de visibilité indéterminée
Loading...

Dates et versions

inserm-00498762 , version 1 (08-07-2010)

Identifiants

Citer

Anne Janin, Hideyuki Murata, Christophe Leboeuf, Jean-Michel Cayuela, Eliane Gluckman, et al.. Donor-derived oral squamous cell carcinoma after allogeneic bone marrow transplantation.. Blood, 2009, 113 (8), pp.1834-40. ⟨10.1182/blood-2008-07-171702⟩. ⟨inserm-00498762⟩
160 Consultations
1 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More