GluR5 kainate receptor activation in interneurons increases tonic inhibition of pyramidal cells. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Nature Neuroscience Year : 1998

GluR5 kainate receptor activation in interneurons increases tonic inhibition of pyramidal cells.

Abstract

We studied the modulation of GABAergic inhibition by glutamate and kainate acting on GluR5-containing kainate receptors in the CA1 hippocampal region. Glutamate, kainate or ATPA, a selective agonist of GluR5-containing receptors, generates an inward current in inhibitory interneurons and cause repetitive action potential firing. This results in a massive increase of tonic GABAergic inhibition in the somata and apical dendrites of pyramidal neurons. These effects are prevented by the GluR5 antagonist LY 293558. Electrical stimulation of excitatory afferents generates kainate receptor-mediated excitatory postsynaptic currents (EPSCs) and action potentials in identified interneurons that project to the dendrites and somata of pyramidal neurons. Therefore glutamate acting on kainate receptors containing the GluR5 subunit may provide a protective mechanism against hyperexcitability.
Embargoed file
Embargoed file
Visibility date is undetermined
Loading...

Dates and versions

inserm-00487305 , version 1 (28-05-2010)

Identifiers

Cite

Rosa Cossart, Monique Esclapez, June C. Hirsch, Christophe Bernard, Yehezkel Ben-Ari. GluR5 kainate receptor activation in interneurons increases tonic inhibition of pyramidal cells.. Nature Neuroscience, 1998, 1 (6), pp.470-8. ⟨10.1038/2185⟩. ⟨inserm-00487305⟩

Collections

INSERM UNIV-AMU
217 View
2 Download

Altmetric

Share

Gmail Facebook X LinkedIn More