Kainate, a double agent that generates seizures: two decades of progress. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Trends in Neurosciences Year : 2000

Kainate, a double agent that generates seizures: two decades of progress.

Abstract

Studies using kainate, an excitatory amino acid extracted from a seaweed, have provided major contributions to the understanding of epileptogenesis. Here we review pioneering and more recent studies aimed at determining how kainate generates seizures and, in particular, how inhibition is altered during seizures. We focus on target and subunit-specific effects of kainate on hippocampal pyramidal neurons and interneurons that lead to an excitation of both types of neurons and thus to the parallel increase of glutamatergic and GABAergic spontaneous currents. We propose that kainate excites all its targets, the net consequence depending on the level of activity of the network.
Embargoed file
Embargoed file
Visibility date is undetermined
Loading...

Dates and versions

inserm-00485223 , version 1 (20-05-2010)

Identifiers

  • HAL Id : inserm-00485223 , version 1
  • PUBMED : 11074268

Cite

Yehezkel Ben-Ari, Rosa Cossart. Kainate, a double agent that generates seizures: two decades of progress.. Trends in Neurosciences, 2000, 23 (11), pp.580-7. ⟨inserm-00485223⟩

Collections

INSERM UNIV-AMU
54 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More