Developing networks play a similar melody. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Trends in Neurosciences Year : 2001

Developing networks play a similar melody.

Abstract

During development, when synapses start to be established, a primitive form of network-driven activity provides most of the synaptic activity. This pattern enables a high degree of synchrony in immature neurons in spite of the small number of functional synapses and could participate in activity-dependent growth and synapse formation. Relying on the giant depolarizing potentials that provide most of the synaptic activity in the developing hippocampus, this article reviews the common properties and generating mechanisms of these patterns, and particularly the role of the early depolarizing action of GABA(A) and glycine receptors and the sequential expression of GABA and glutamate synapses. Patterns similar to giant depolarizing potentials have been observed in a wide range of structures and species suggesting that there is a temporal template throughout evolution that constitutes an essential step in the formation of functional networks.
Embargoed file
Embargoed file
Ne sera jamais visible
Loading...

Dates and versions

inserm-00484881 , version 1 (19-05-2010)

Identifiers

  • HAL Id : inserm-00484881 , version 1
  • PUBMED : 11356508

Cite

Yehezkel Ben-Ari. Developing networks play a similar melody.. Trends in Neurosciences, 2001, 24 (6), pp.353-60. ⟨inserm-00484881⟩

Collections

INSERM UNIV-AMU
72 View
1 Download

Altmetric

Share

Gmail Facebook X LinkedIn More