Excitatory actions of gaba during development: the nature of the nurture. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Nature Reviews Neuroscience Year : 2002

Excitatory actions of gaba during development: the nature of the nurture.

Abstract

In the immature brain, GABA (gamma-aminobutyric acid) is excitatory, and GABA-releasing synapses are formed before glutamatergic contacts in a wide range of species and structures. GABA becomes inhibitory by the delayed expression of a chloride exporter, leading to a negative shift in the reversal potential for choride ions. I propose that this mechanism provides a solution to the problem of how to excite developing neurons to promote growth and synapse formation while avoiding the potentially toxic effects of a mismatch between GABA-mediated inhibition and glutamatergic excitation. As key elements of this cascade are activity dependent, the formation of inhibition adds an element of nurture to the construction of cortical networks.
Embargoed file
Embargoed file
Visibility date is undetermined
Loading...

Dates and versions

inserm-00484852 , version 1 (19-05-2010)

Identifiers

Cite

Yehezkel Ben-Ari. Excitatory actions of gaba during development: the nature of the nurture.. Nature Reviews Neuroscience, 2002, 3 (9), pp.728-39. ⟨10.1038/nrn920⟩. ⟨inserm-00484852⟩

Collections

INSERM UNIV-AMU
540 View
2 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More