Expression of cortical and hippocampal apoptosis-inducing factor (AIF) in aging and Alzheimer's disease. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Neurobiol Aging Year : 2007

Expression of cortical and hippocampal apoptosis-inducing factor (AIF) in aging and Alzheimer's disease.

Abstract

Apoptosis-inducing factor (AIF) is a mitochondrial oxidoreductase originally identified for its role in caspase-independent programmed cell death (PCD). In this study, we investigated AIF protein expression levels in frontal and temporal cortices of normal subjects of various ages, as well as in subjects with Alzheimer's disease (AD). AIF levels were also measured in the hippocampus of age-matched elderly and AD subjects. Amounts of all three AIF isoforms increased significantly with age in both cortical areas. Interestingly, AIF expression levels in the cortex (but not hippocampus) were consistently lower in AD compared to age-matched controls. The up-regulation of cortical AIF in normal aging is consistent with its previously hypothesized role as a free radical scavenger, and may thus represent an adaptive cellular response to compensate for the steady increase in oxidative stress occurring with age.
Embargoed file
Embargoed file
Visibility date is undetermined
Loading...

Dates and versions

inserm-00483900 , version 1 (17-05-2010)

Identifiers

Cite

Stéphanie Reix, Naguib Mechawar, Santos A. Susin, Rémi Quirion, Slavica Krantic. Expression of cortical and hippocampal apoptosis-inducing factor (AIF) in aging and Alzheimer's disease.. Neurobiol Aging, 2007, 28 (3), pp.351-6. ⟨10.1016/j.neurobiolaging.2006.01.003⟩. ⟨inserm-00483900⟩
92 View
0 Download

Altmetric

Share

Gmail Mastodon Facebook X LinkedIn More