Mediators involved in the immunomodulatory effects of apoptotic cells. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Transplantation Year : 2007

Mediators involved in the immunomodulatory effects of apoptotic cells.

Abstract

Immunomodulatory properties are attributed to apoptotic cells. These properties have been used to modulate allogeneic immune responses in experimental transplantation settings. In independent studies, apoptotic cell infusion has been shown to favor hematopoietic cell engraftment, to increase heart graft survival, and to delay the lethal onset of graft-versus-host disease (GVHD). The goal of this review was to discuss how apoptotic cell infusion interferes with graft rejection or host rejection (i.e., GVHD) and to focus on the potential mediators or "perpetuators" involved in apoptotic cell-induced immunomodulation. Particular emphasis on apoptotic cell phagocytosis, transforming growth factor (TGF)-beta secretion, and regulatory T cell induction was performed. Stimulating "naturally" immunosuppressive molecules (i.e., TGF-beta) or immunomodulatory cells ("alternatively-activated" macrophages, certain dendritic cell subsets, or regulatory T cells) in a physiological manner by using apoptotic cell infusion can be a promising way to induce tolerance.

Domains

Immunology
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Dates and versions

inserm-00479706 , version 1 (20-02-2012)

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Philippe Saas, Francis Bonnefoy, Stephanie Kury-Paulin, François M. Kleinclauss, Sylvain Perruche. Mediators involved in the immunomodulatory effects of apoptotic cells.. Transplantation, 2007, 84 (1 Suppl), pp.S31-4. ⟨10.1097/01.tp.0000269113.59857.d6⟩. ⟨inserm-00479706⟩

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