[The future of antibody fragments, made of a single immunoglobulin domain.]
Abstract
Monoclonal antibodies are now established as key therapeutics for a range of diseases including cancer and auto-immunity. However, despite important improvements, these molecules still face several serious limitations including production costs and tumor penetration. A new class of antibody fragments, made of a single immunoglobulin domain, is emerging as an exciting alternative. This review describes the outstanding properties and the first achievements of these domain antibodies. double dagger.
Origin : Publisher files allowed on an open archive
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