Hepatitis E virus and chronic hepatitis in organ-transplant recipients. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles New England Journal of Medicine Year : 2008

Hepatitis E virus and chronic hepatitis in organ-transplant recipients.

Abstract

Hepatitis E virus (HEV) is considered an agent responsible for acute hepatitis that does not progress to chronic hepatitis. We identified 14 cases of acute HEV infection in three patients receiving liver transplants, nine receiving kidney transplants, and two receiving kidney and pancreas transplants. All patients were positive for serum HEV RNA. Chronic hepatitis developed in eight patients, as confirmed by persistently elevated aminotransferase levels, serum HEV RNA, and histologic features of chronic hepatitis. The time from transplantation to diagnosis was significantly shorter and the total counts of lymphocytes and of CD2, CD3, and CD4 T cells were significantly lower in patients in whom chronic disease developed.

Dates and versions

inserm-00409083 , version 1 (05-08-2009)

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Nassim Kamar, Janick Selves, Jean-Michel Mansuy, Leila Ouezzani, Jean-Marie Péron, et al.. Hepatitis E virus and chronic hepatitis in organ-transplant recipients.. New England Journal of Medicine, 2008, 358 (8), pp.811-7. ⟨10.1056/NEJMoa0706992⟩. ⟨inserm-00409083⟩
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