Coordinated and spatial upregulation of arc in striatonigral neurons correlates with L-dopa-induced behavioral sensitization in dyskinetic rats. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Journal of Neuropathology and Experimental Neurology Year : 2005

Coordinated and spatial upregulation of arc in striatonigral neurons correlates with L-dopa-induced behavioral sensitization in dyskinetic rats.

Abstract

Although oral administration of L-Dopa remains the best therapy for Parkinson disease, its long-term administration causes the appearance of abnormal involuntary movements such as dyskinesia. Although persistent striatal induction of some genes has already been associated with such pathologic profiles in hemiparkinsonian rats, molecular and cellular mechanisms underlying such long-term adaptations remain to be elucidated. In this study, using a rat model of L-Dopa-induced dyskinesia, we report that activity regulated cytoskeletal (Arc)-associated protein is strongly upregulated in the lesioned striatum and that the extent of its induction further varies according to the occurrence or absence of locomotor sensitization. Moreover, Arc is preferentially induced, along with FosB, nur77, and homer-1a, in striatonigral neurons, which express mRNA encoding the precursor of dynorphin. Given the likely importance of Arc in the regulation of cytoskeleton during synaptic plasticity, its upregulation supports the hypothesis that a relationship exists between cytoskeletal modifications and the longlasting action of chronically administrated L-Dopa.
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Dates and versions

inserm-00391107 , version 1 (03-06-2009)

Identifiers

  • HAL Id : inserm-00391107 , version 1
  • PUBMED : 16254488

Cite

Véronique Sgambato-Faure, Virginie Buggia, François Gilbert, Daniel Lévesque, Alim-Louis Benabid, et al.. Coordinated and spatial upregulation of arc in striatonigral neurons correlates with L-dopa-induced behavioral sensitization in dyskinetic rats.. Journal of Neuropathology and Experimental Neurology, 2005, 64 (11), pp.936-47. ⟨inserm-00391107⟩

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