Cognitive impairments in the STOP null mouse model of schizophrenia. - Inserm - Institut national de la santé et de la recherche médicale Access content directly
Journal Articles Behavioral Neuroscience Year : 2007

Cognitive impairments in the STOP null mouse model of schizophrenia.

Abstract

Cognitive dysfunction is a primary and persisting core deficit of schizophrenia that is marginally improved by antipsychotic treatment. Adult mice that lack the stable tubule-only polypeptide (STOP) have neurochemical and behavioral abnormalities that model some features of schizophrenia. Recognition and long-term memory in the STOP null mouse were tested with the novel object recognition task and an olfactory discrimination task, respectively. Researchers examined the brains from STOP null mice to determine whether differences in task performance were associated with alterations in brain morphology. STOP null mice displayed deficits in both recognition and long-term memory. These behavioral deficits were accompanied by a massive enlargement of the cerebral ventricular system as well as by reductions in volume of cortical and diencephalic structures. In addition to deficits in recognition and long-term memory, STOP null mice displayed exaggerated neuroanatomical deficits somewhat reminiscent of those observed among individuals with schizophrenia.
Fichier principal
Vignette du fichier
powell_et_al_revised-4_2_.pdf (171.84 Ko) Télécharger le fichier
stop_figures_2007.pdf (344.38 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)

Dates and versions

inserm-00380034 , version 1 (13-05-2009)

Identifiers

Cite

Kelly J. Powell, Sarah E. Hori, Ronald Leslie, Annie Andrieux, Heather Schellinck, et al.. Cognitive impairments in the STOP null mouse model of schizophrenia.. Behavioral Neuroscience, 2007, 121 (5), pp.826-35. ⟨10.1037/0735-7044.121.5.826⟩. ⟨inserm-00380034⟩
180 View
577 Download

Altmetric

Share

Gmail Facebook X LinkedIn More